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Ellipsis Biotherapeutics completes four contracts for high-throughput genotyping Servies
SARASOTA, Fla., | Feb. 21, 2006
DNAPrint Genomics, Inc. (OTCBB: DNAG) today announced that Ellipsis Biotherapeutics, Inc. will complete a record quarter of revenue generation from high volume SNP genotyping. A significant portion of the revenue came from four contracts, including a major American university, two United Kingdom academic research groups, and one Toronto based academic hospital program. Ellipsis, acquired by the Company in November 2005, conducts SNP genotyping using state-of-the-art technologies. These include single-base primer extension platforms from Beckman Coulter, Inc. and the GoldenGate™ platform from Illumina, Inc. With a choice of platforms and scales for performing work, Ellipsis supports companies through the entire scope of their genotyping efforts. Projects include both high throughput screening of multiple samples as well as finer mapping to clarify associations of genetic predisposition in a variety of human diseases.
“Our goal is to deliver the highest quality SNP genotyping services to the marketplace, including
project development, ongoing scientific advice and data analysis and interpretation,” commented
Dr. Laurence Rubin, founder of Ellipsis. “Ellipsis has completed these projects on schedule and
within budget. Our services have been instrumental in helping scientists publish their work in
respected scientific journals. In addition to completing large volume contract services for a
variety of projects, we are participating in novel research programs, which has always been part
of the company’s focus,” he added.
“We are extremely pleased that Ellipsis Biotherapeutics has met its first major milestone and has
done it with better than budgeted goals and objectives. We expect that Ellipsis will continue to
contribute to our revenue growth and assist our core pursuit of pharmaceuticals and diagnostics,”
said Richard Gabriel, Chief Executive Officer and President of DNAPrint Genomics, Inc.
For further information on genotyping and other DNA services, please contact Ellipsis
Biotherapeutics at: 416-586-0947.
About DNAPrint Genomics, Inc.
DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of genomics-based products and services in
two primary markets: biomedical and forensics. DNAPrint Pharmaceuticals, Inc., a wholly owned
subsidiary, develops diagnostic tests and theranostic products (drug/test combinations) using the
Company's proprietary ancestry-informed genetic marker studies combined with proprietary computational
modeling technology. Computational Biology and Pharmacogenomics services are also offered externally
to biopharmaceutical companies. The Company's first theranostic product is PT-401, a "Super EPO"
(erythropoietin) dimer protein drug for treatment of anemia in renal dialysis patients (end stage renal
disease). Pre-clinical and clinical development of all the Company's drug candidates will benefit from
simulated pre-trials to better design actual trials and are targeted to patients with a genetic profile indicating their propensity to have the best clinical response. DNAPrint is proud of its continued dedication to
developing and supplying new technological advances in law enforcement and consumer ancestry heritage
interests. Please refer to www.dnaprint.com for information on law enforcement and consumer applications
which include DNAWITNESS(TM), RETINOME(TM), ANCESTRYbyDNA(TM) and EURO-DNA(TM).
DNAWitness-Y and DNAWitness-Mito are two tests offered by the Company for additional forensics
work. The results from these tests may be used as identification tools when a DNA sample is deteriorated
or compromised or other DNA testing fails to yield acceptable results. The Company also performs
contract genotyping and other DNA services through its Ellipsis Biotherapeutics group in Toronto, Canada.
Forward-Looking Statements
All statements in this press release that are not historical are forward-looking statements. Such statements
are subject to risks and uncertainties that could cause actual results to differ materially from those
projected, including, but not limited to, uncertainties relating to technologies, product development,
manufacturing, market acceptance, cost and pricing of DNAPrint's products, dependence on collaborations
and partners, regulatory approvals, competition, intellectual property of others, and patent protection and
litigation. DNAPrint Genomics, Inc. expressly disclaims any obligation or undertaking, except as may be
required by applicable law or regulation, to release publicly any updates or revisions to any forwardlooking
statements contained herein to reflect any change in DNAPrint's expectations with regard thereto or
any change in events, conditions, or circumstances on which any such statements are based.
DNAPrint Genomics expands high-throughput genotyping capacity
SARASOTA, Fla., | Jan. 31, 2006
DNAPrint Genomics, Inc. (OTCBB: DNAG) today announced the
expansion of the Company’s high-throughput genotyping capacity from 1.3 million to more than 3.9 million
genotypes per day.
“Multiplexing and advanced automation protocols provide the flexibility to process large or small genotyping
studies without compromising cost per genotype,” stated DNAPrint Genomics President and Chief Executive
Officer Richard Gabriel. “Increasing high-volume throughput advances our ability to determine genotypes at
economical costs to our customers and business partners. Coupled with our population ancestry technology, we
can achieve better research results at a business-smart price.”
The increase in processing capacity particularly targets the pharmaceuticals and healthcare market. It enables the
Company to process clinical trials samples to ensure that patient population groups are accurately
categorized, and perform large scale genotyping work for the various industries interested.
DNAPrint Genomics Founder and Chief Scientific Officer Tony N. Frudakis, Ph.D., noted that the Company has
key advantages over other laboratories offering genotyping services. “We are unique in our expertise in
population structure analysis using our Ancestry Informative Markers (AIM),” said Dr. Frudakis. “We can
demonstrate to our customers that failure to understand the ancestral or biological structure of their study
population can significantly confound and even compromise genetic studies. We offer a unique approach to
maximizing the probability of success in pharmacogenetic, predisposition, risk profiling and susceptibility
studies t h at many companies are pursuing alongside drug and diagnostics development.”
DNA Print has genotyping facilities at its Sarasota headquarters and at laboratories in Richmond, Calif., and
Toronto, Canada, which utilize sophisticated equipment manufactured by Beckman Coulter and Illumina, Inc.
The U.S. laboratories are genotyping with the ultra sensitive and robust GenomeLab SNPstream from Beckman
Coulter while the Toronto lab is equipped with the Illumina bead machine and is also offering HAP MAP SNP
genotyping services.
“Results from the GenomeLab SNPstream from Beckman Coulter are 99+% reproducible, providing the kind of
validation that we believe the U.S. Food and Drug Administration (FDA) is seeking for its clinical trials data,”
Dr. Frudakis noted.
About DNAPrint Genomics, Inc.
DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of genomics-based products and services in two
primary markets: biomedical and forensics. DNAPrint Pharmaceuticals, Inc., a wholly owned subsidiary,
develops diagnostic tests and theranostic products (drug/test combinations) using the Company's proprietary
ancestry-informed genetic marker studies combined with proprietary computational modeling technology.
Computational Biology and Pharmacogenomics services are also offered externally to biopharmaceutical
companies. The Company's first theranostic product is PT-401, a "Super EPO" (erythropoietin) dimer protein
drug for treatment of anemia in renal dialysis patients (end stage renal disease). Pre-clinical and clinical
development of all the Company's drug candidates will benefit from simulated pre-trials to better design actual
trials and are targeted to patients with a genetic profile indicating their propensity to have the best clinical
response. DNAPrint is proud of its continued dedication to developing and supplying new technological
advances in law enforcement and consumer ancestry heritage interests. Please refer to www.dnaprint.com for
information on law enforcement and consumer applications which include DNAWITNESS(TM),
RETINOME(TM), ANCESTRYbyDNA(TM) and EURO-DNA(TM). Recently announced and as a part of the
Company’s Trace Genetics acquisition, DNAWitness-Y and DNAWitness-Mito are two new tests that can be
used as an identification tool when other DNA testing either fails to yield results or the sample might be too
deteriorated.
Forward-Looking Statements
All statements in this press release that are not historical are forward-looking statements. Such
statements are subject to risks and uncertainties that could cause actual results to differ materially from
those projected, including, but not limited to, uncertainties relating to technologies, product
development, manufacturing, market acceptance, cost and pricing of DNAPrint's products, dependence
on collaborations and partners, regulatory approvals, competition, intellectual property of others, and
patent protection and litigation. DNAPrint Genomics, Inc. expressly disclaims any obligation or
undertaking, except as may be required by applicable law or regulation, to release publicly any
updates or revisions to any forward-looking statements contained herein to reflect any change in
DNAPrint's expectations with regard thereto or any change in events, conditions, or circumstances on
which any such statements are based.
DNAPrint Genomics completes Acquistion of Ellipsis Biotherapeutics
SARASOTA, Fla., | Dec. 22, 2005
DNAPrint Genomics, Inc. (OTCBB: DNAG) today
announced the completion of its previously announced acquisition of Ellipsis Biotherapeutics
Corporation, which will operate as a drug and diagnostic subsidiary.
Ellipsis Biotherapeutics, formerly privately held, is retaining its name and will function as a
Canadian company from its corporate headquarters in Toronto, Ontario. Ellipsis will retain its
existing personnel and continue to be managed by Dr. Laurence Rubin, who is also the Director of
the Division of Rheumatology at St. Michael's Hospital in Toronto. His research has focused on the
genetic determinants of osteoporosis, rheumatoid arthritis and other inflammatory diseases. He has
been with Ellipsis since 2000.
“The Ellipsis Biotherapeutics acquisition strengthens our position in the diagnostic and clinical
patient testing market,” stated Richard Gabriel, Chief Executive Officer and President of DNAPrint
Genomics. “It also provides potential business opportunities with several large pharmaceutical and
animal health care companies currently utilizing Ellipsis’s high throughput screening technologies.”
Ellipsis is located in downtown Toronto in close proximity to the University of Toronto campus, the
recently opened MaRS Centre and major academic teaching hospitals. Using the Beckman Coulter
GenomeLab SNPstream and the Illumina Beadstation, Ellipsis performs contract SNP genotyping for
academic centers, hospitals, human health care corporations and biotech companies in diverse areas
covering human, plant and animal analyses. In addition, Ellipsis has acquired a diverse portfolio of
genetic data and intellectual property from unique patient populations, specifically with
Inflammatory Bowel Disease (Crohn’s disease) including last year’s publications of the discovery of
a gene for Crohn’s disease. Diagnostic applications are currently under development in this and
related areas of autoimmune inflammatory disorders.
“We are very excited to be part of the DNAPrint group of companies,” Dr. Laurence Rubin stated.
“Our core competencies provide a unique fit for future growth and development of our contract
services as well as opportunities to accelerate novel research programs and collaborations.”
About DNAPrint Genomics, Inc.
DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of genomics-based products and
services in two primary markets: biomedical and forensics. DNAPrint Pharmaceuticals, Inc., a
wholly owned subsidiary, develops diagnostic tests and theranostic products (drug/test combinations)
using the Company's proprietary ancestry-informed genetic marker studies combined with
proprietary computational modeling technology. Computational Biology and Pharmacogenomics
services are also offered externally to biopharmaceutical companies. The Company's first theranostic
product is PT-401, a "Super EPO" (erythropoietin) dimer protein drug for treatment of anemia in
renal dialysis patients (end stage renal disease). Pre-clinical and clinical development of all the Company's drug candidates will benefit from simulated pre-trials to better design actual trials and are
targeted to patients with a genetic profile indicating their propensity to have the best clinical
response. DNAPrint is proud of its continued dedication to developing and supplying new
technological advances in law enforcement and consumer ancestry heritage interests. Please refer to
www.dnaprint.com for information on law enforcement and consumer applications which include
DNAWITNESS(TM), RETINOME(TM), ANCESTRYbyDNA(TM) and EURO-DNA(TM).
Forward-Looking Statements
All statements in this press release that are not historical are forward-looking statements. Such
statements are subject to risks and uncertainties that could cause actual results to differ materially
from those projected, including, but not limited to, uncertainties relating to technologies, product
development, manufacturing, market acceptance, cost and pricing of DNAPrint's products,
dependence on collaborations and partners, regulatory approvals, competition, intellectual property
of others, and patent protection and litigation. DNAPrint Genomics, Inc. expressly disclaims any
obligation or undertaking to release publicly any updates or revisions to any forward-looking
statements contained herein to reflect any change in DNAPrint's expectations with regard thereto or
any change in events, conditions, or circumstances on which any such statements are based.
Ellipsis Biotherapeutics Corporation offers expanded SNP genotyping services
TORONTO, Canada | May 24, 2005
Ellipsis Biotherapeutics Corporation announced today that it now offers SNP genotyping
using both the Illumina GoldenGate™ and Beckman Coulter SNPstream™ technologies.
“The addition of the Illumina system to our existing SNPstream platform
allows us the unique opportunity to accomodate all SNP genotyping projects,
ranging in size from quite small to very large”, commented Laurence Rubin,
CEO of Ellipsis. “We are very excited to offer this complete suite of
SNP genotyping solutions to our clients”.
Ellipsis Biotherapeutics Corporation
was founded in 1997 to commercialize the disease gene discovery efforts of
its founders, primarily in the area of
inflammatory disease. Since then, it has leveraged its expertise in SNP genotyping
to provide high quality service to a variety of clients in academic, government
and industrial research settings. For more information, see the company’s
website at www.ellipsisbio.com, or contact genotyping@ellipsisbio.com.
Ellipsis Biotherapeutics Corporation Identifies
Genes Involved in Crohn's Disease
TORONTO, Canada | April 22, 2004
Findings Published in Nature Genetics.
Ellipsis Biotherapeutics Corporation, a drug and diagnostics discovery company, together with academic collaborators, has isolated novel genes that predispose people to development of Crohn's disease. Their findings appeared online April 11 in the journal Nature Genetics (www.nature.com/ng/) and are published in the current issue of the journal.
"Isolating this gene is a critical step towards improved diagnosis of this disease and developing better therapies for Crohn's sufferers, who have an urgent need for better treatment" says Katherine Siminovitch, President and Chief Operating Officer of Ellipsis. Crohn's disease is an inflammatory bowel disease of increasing prevalence in industrialized nations. Existing treatments are considered unsatisfactory, often requiring recurring hospitalization and surgeries.
The Crohn's discovery was made using Ellipsis' genetic analysis technologies to identify genes using DNA samples from family groups. The identified genes produce proteins that sit on the surface of cells lining the gastro-intestinal tract and regulate how substances enter and exit these cells. In a majority of Crohn's disease patients, these proteins function improperly and allow toxins easier access to the cell.
The ability to test for this altered protein will help physicians distinguish between Crohn's disease and ulcerative colitis, the other major form of inflammatory bowel disease known. The alteration discovered by Ellipsis and its collaborators is not present in ulcerative colitis, so this gene alteration provides a diagnostic test to help distinguish between the two diseases. Ellipsis anticipates that this information can also be used to diagnose Crohn's disease at an earlier stage and to develop new approaches to treatment. The discovery of these novel genes will also enable the development of small molecules that can regulate these disease pathways.
"We are very excited about this discovery," says Siminovitch. "It provides further demonstration of the success of Ellipsis technologies and sheds light on the biological processes that lead to many chronic inflammatory conditions, such as Crohn's disease and rheumatoid arthritis, which have similar causes even though the target organs differ."
Ellipsis Biotherapeutics Corporation is a privately held drug and diagnostic discovery company developing novel medicines for human diseases where existing therapies are unable to address patient needs. The company's lead programs are in Alzheimer's Disease and Inflammatory Bowel Disease, where new treatment regimens are needed not only to treat symptoms, but to prevent and cure the underlying disorder. Through both independent programs and strategic alliances, Ellipsis intends to commercialize its discoveries and make better medicines for patients.
Ellipsis Biotherapeutics Corporation to broadcast SNP
genotyping technology web seminar hosted by Beckman Coulter,
Inc.
TORONTO, Canada | April 15, 2004
Staff from Ellipsis Biotherapeutics Corporation's SNP genotyping service will present a web-based seminar entitled "Automated scalable SNP genotyping solutions using the GenomeLab SNPstream genotyping system". The seminar, hosted by Beckman Coulter, Inc., will be on Thursday, April 15, 2004, at 12:00 noon EST. Please visit www.beckmancoulter.com/SNPseminar for details and registration.
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